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Do older patients with acute ischemic stroke have worse outcomes than younger patients after treatment with thrombolytic agents? To find out, researchers compared outcomes in 23,334 patients from the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) who received thrombolytics (alteplase) an average of 145 minutes after stroke onset with outcomes in 6166 control patients from the Virtual International Stroke Trials Archive (VISTA) database who received a nonthrombolytic neuroprotective agent or placebo. Overall, 3439 patients were older than 80 (average age, 85). All analyses were adjusted for age and baseline stroke severity.
Among the entire cohort, functional outcomes at 90 days as measured o…