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Some authors recommend eradication of Staphylococcus aureus colonization as a means of preventing recurrent infections. To study the efficacy of this recommendation, researchers randomized 147 children with community-associated S. aureus skin infections and colonization, who were recruited from ten sites in St. Louis, to 5 days of eradication measures (hygiene education, twice-daily intranasal mupirocin, and daily chlorhexidine body washes) performed by either the infected child only (index group) or the child's entire household.
Eradication was successful in 50% of the index group and 51% of the household group. Among 126 children who completed 12-month follow-up, the incidence of recurrent soft- tissue infections was significantly higher i…