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As part of a continuous quality improvement initiative, investigators analyzed data from 5 community and 6 tertiary hospitals in the U.S. that implemented an evidence-based, 6-hour sepsis resuscitation bundle for patients with suspected sepsis:
1) Measure serum lactate
2) Obtain blood cultures before antibiotic administration
3) Administer broad-spectrum antibiotic within 3 hours of emergency department (ED) admission and within 1 hour of non-ED intensive care unit admission
4) In the event of hypotension, serum lactate ≥4 mmol/L, or both:
Administer an initial minimum of 20 mL/kg of crystalloid or an equivalent
If hypotension does not respond to initial fluid resuscitation, administer vasopressors to maintain mean arterial pressure >65 mm Hg
5) I…