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To address the common belief that ketamine increases intraocular pressure, researchers prospectively evaluated the effect of intravenous ketamine on intraocular pressure in previously healthy children ages 1 to15 years who underwent procedural sedation for nonocular complaints at a tertiary care pediatric emergency department. Intraocular pressure was measured with a Tono-Pen XL tonometer immediately after and 2.5, 5, and 10 minutes after ketamine administration. A pressure difference of at least 15% was considered clinically relevant.
Over 16 months, 80 children were enrolled and received a mean ketamine does of 1.6 mg/kg. No clinically relevant difference was found between mean intraocular pressure immediately after and 2.5 minutes after k…