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To evaluate whether pulmonary embolism (PE) can safely be excluded using a diagnostic strategy combining initial Wells score (see table) and point-of-care d-dimer results, investigators prospectively enrolled 598 adults (mean age, 48 years; 71% female) with suspected PE who presented to primary care settings in the Netherlands. Eligible participants had at least one of the following symptoms: Sudden unexplained dyspnea, deterioration or existing dyspnea, inspiratory pain, or unexplained cough. Patients who were on anticoagulant treatment or pregnant were excluded.
Patients were classified as low risk if they had an initial Wells score ≤4 and a negative point-of-care d-dimer (Clearview Simplify) result. All patients were referred to secondary…
