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Delirium is highly prevalent in critically ill patients and is associated with excess mortality, longer lengths of stay, greater functional decline, and higher healthcare costs. Antipsychotics (both haloperidol and newer atypical agents such as risperidone, olanzapine [Zyprexa], quetiapine [Seroquel], and ziprasidone [Geodon]) commonly are used in the intensive care unit to treat patients with delirium, despite absence of data from placebo-controlled clinical trials in ICU patients to support this practice.
In the Modifying the INcidence of Delirium (MIND) trial, researchers conducted a randomized double-blind trial in 101 mechanically ventilated adults from the surgical and medical ICUs of six tertiary care medical centers. (A total of 3196…