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Hospital-acquired infections contribute substantially to rising healthcare costs as well as in-hospital morbidity and mortality. Nosocomial infections caused by gram-negative organisms are a major concern, as these organisms account for more than 30% of hospital-acquired infections and 70% of infections in the intensive care unit.
Gram-negative bacteria have proven particularly adept at developing novel resistance mechanisms, and they employ a variety of resistance strategies. In this review, the authors detail the microbiology, resistance patterns, management strategies, and treatment recommendations for three commonly encountered hospital-acquired infections: pneumonia, bacteremia, and urinary tract infections. In each of these conditions,…