Circumcision Reduces Risk for HIV Infection

Two large randomized trials in Africa showed that male circumcision reduces the risk for HIV infection by more than 50%.

Male circumcision has been proposed as a way to reduce the risk for HIV infection. Such a benefit is biologically plausible because of the high density of HIV target cells on the foreskin’s inner surface. Now, the protective effect and safety of circumcision have been assessed in two randomized trials. Both studies were stopped early after interim analyses showed clear benefit of circumcision.

In Kisumu, Kenya, 2784 HIV-negative, sexually active men aged 18–24 (median age, 20) were randomized to receive circumcision or delayed circumcision. Participants underwent clinical examination and HIV counseling and testing on entry and at follow-up visits over 24 months. During the study, 22 men in the circumcision group and 47 men in the control gro…

Reviewing Author

Mary E. Wilson, MD

Circumcision Reduces Risk for HIV Infection

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Reviewing Author