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After transmission of wild poliovirus is stopped, global use of live oral poliovirus vaccine (OPV) should cease, to avoid the emergence of neurovirulent vaccine-derived virus with potential for transmission. But will inactivated poliovirus vaccine (IPV) be immunogenic in tropical developing countries that have relied on OPV to control polio?
To find out, investigators in Cuba randomized healthy full-term infants to receive diphtheria-pertussis-tetanus (DPT) and Haemophilus influenzae type b (Hib) vaccines, with or without IPV, in a three-dose schedule (ages 6, 10, and 14 weeks). Another group received DPT-Hib-IPV in a two-dose schedule (ages 8 and 16 weeks). Serum samples were collected before and approximately 4 weeks after the final study-…