In patients with advanced HIV infection, slow but steady increases in CD4-cell counts after therapy initiation suggest that normalization of counts may be possible.
Combination antiretroviral therapy (ART) has led to a dramatic reduction in clinical events and to improved survival of HIV-infected patients. However, in some patients, CD4-cell counts remain below normal even after several years of ART. Is normalization of CD4-cell counts possible in patients with advanced HIV infection? Investigators in Europe sought to answer this question using data from EuroSIDA, a large observational cohort study.
The researchers focused on 1835 previously antiretroviral-naive patients who had started combination ART during the EuroSIDA study and had subsequently achieved at least two consecutive HIV RNA levels <50 copies/mL; all had CD4-cell counts measured during the 6 months before therapy initiation. Changes in CD…
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)