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Hepatitis C virus (HCV) infection progresses more rapidly to fibrosis among persons who are immunosuppressed than among those who are not. Most studies on this topic have involved patients who became immunocompromised after chronic HCV infection was already established. To learn more about individuals who develop acute HCV infection after becoming immunocompromised, researchers in New York City investigated the rate of HCV disease progression in a small cohort of HIV-infected men with recent HCV acquisition (determined by seroconversion to HCV antibody positivity, elevation in alanine aminotransferase level, and fluctuation of HCV viral load).
Participants underwent percutaneous liver biopsy after hepatitis onset (9 of them from 3 to 21 week…