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Streptococcus pneumoniae is a leading cause of meningitis and respiratory tract infections. In an industry-sponsored study, researchers in Spain examined whether changes in S. pneumoniae nonsusceptibility in adults and children correlated with licensure of 7-valent pneumococcal conjugate vaccine (PCV-7) for immunization of children and of respiratory quinolones for treatment in adults.
All invasive S. pneumoniae isolates received at the Spanish National Reference Pneumococcal Laboratory from January 2000 through August 2007 (n=12,957) were serotyped, and their susceptibility to penicillin, erythromycin, and levofloxacin was determined. Data on PCV-7 distribution during that period were obtained from the manufacturer; figures for antibiotic c…