Invasive Fungal Infections in Hematopoietic Stem-Cell Transplant Recipients

The survival rate of patients with invasive aspergillosis has improved, but the incidence of IFIs caused by other organisms is increasing.

Hematopoietic stem-cell transplant recipients are at high risk for invasive fungal infections (IFIs; JW Infect Dis Nov 21 2007). However, changes in antifungal prophylaxis and in transplant practices during the previous 2 decades have altered the epidemiology of IFIs in these patients. To investigate recent trends in such infections, investigators used data for July 2004 through September 2007 from the Prospective Antifungal Therapy Alliance, a prospective, multicenter, observational registry of IFIs in the U.S. and Canada.

Data were analyzed for 234 adults with 250 proven or probable IFIs treated at 16 medical centers. Invasive aspergillosis (IA) was the most common IFI (59% of cases). Although the incidence of IA was stable during the stud…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)