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Vitamin D metabolites have been shown to induce macrophage activity against Mycobacterium tuberculosis in vitro, and supplementation was used to treat TB during the preantibiotic era. In addition, two recent small studies have suggested that vitamin D supplementation provides clinical benefit in patients with active TB.
To examine whether such supplementation might improve clinical response to treatment, researchers performed a randomized, double-blind, placebo-controlled study in Guinea-Bissau among 365 adults with active pulmonary TB who were initiating antituberculosis therapy. Among these, 281 had follow-up at 12 months. The treatment group received 100,000 IU of cholecalciferol on enrollment and again at 5 and 8 months.
No serious advers…