2009 H1N1 Influenza in Organ-Transplant Recipients

Almost a third of these patients developed pneumonia and 4% died; early antiviral therapy reduced the likelihood of intensive care unit admission and of death.

The 2009 H1N1 influenza virus has been shown to cause severe disease in some groups, including children and pregnant women. To characterize clinical illness and assess outcomes in sold-organ transplant recipients, investigators conducted a cohort study involving children and adults with kidney, liver, heart, lung, or other organ transplants who were receiving at least one immunosuppressive drug and who had microbiologically confirmed influenza A between April and December 2009. Patients who had acquired influenza nosocomially or while receiving antiviral prophylaxis were excluded. The final study cohort consisted of 237 patients from 26 transplant centers (25 in North America, 1 in Europe).

Median time from transplantation was 3.6 years. Thi…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

2009 H1N1 Influenza in Organ-Transplant Recipients

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Reviewing Author