Predicting Treatment Success for Hepatitis C Among HIV-Infected Patients

The rs12979860 CC genotype was associated with an increased likelihood of sustained viral response after pegylated interferon alfa-2/ribavirin treatment.

The IL28B gene encodes for type III interferon. A single nucleotide polymorphism (SNP) near this gene, rs12979860, has been associated with differences in sustained virologic response (SVR) among patients receiving pegylated interferon/ribavirin therapy for hepatitis C virus (HCV) infection. Specifically, the rs12979860 CC genotype is associated with a better outcome than either the TC or the TT genotype — at least in patients with HCV monoinfection. Researchers in Spain recently showed this association in HCV/HIV-coinfected patients (JW AIDS Clin Care May 17 2010). Now, another research group in Spain has published its findings on such individuals.

These investigators assessed outcomes among 154 HCV/HIV-coinfected patients who initiated peg…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Predicting Treatment Success for Hepatitis C Among HIV-Infected Patients

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Reviewing Author