Very Early Cryptococcosis After Solid Organ Transplantation

Nine of 175 solid-organ–transplant recipients who developed cryptococcosis did so within 30 days; liver-transplant recipients were at highest risk for such very early onset.

Cryptococcosis is a known complication of solid-organ transplantation (SOT). Most cases occur from 16 to 21 months after transplantation, but a few develop within 30 days. The clinical characteristics of these very early onset cases have not been described. Now, a consortium of physicians who follow SOT patients with cryptococcosis have detailed their experience with very early onset disease.

A total of 175 cases of cryptococcosis after SOT were included in the multicenter cohort; 9 (5%) occurred ≤30 days after transplantation. Five of these nine patients (56%) had liver transplants compared with 43 of 166 patients (26%) who developed cryptococcosis later (P=0.05). Compared with later-onset cryptococcosis, very early onset disease was signif…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)