Fluoroquinolone use during the preceding 6 months, presence of a urinary catheter, and recent hospitalization were independent risk factors for fluoroquinolone resistance.
Previously, fluoroquinolones (FQs) were the drugs of choice for community-onset urinary tract infections (UTIs). Escherichia coli, the most common uropathogen, was highly susceptible to these agents. Now, however, the situation is changing, with the emergence of FQ-resistant E. coli strains in the community.
To identify patient-related and environmental risk factors for FQ resistance, researchers in the Netherlands conducted a multicenter study involving adults who presented with community-onset febrile UTIs from 2004 through 2009 (n=787). In 420 (53%) of these patients, E. coli was the causal pathogen. Fifty-one (12%) of the 420 E. coli isolates showed FQ resistance. On multivariate analysis, risk factors for FQ-resistant E. coli were FQ us…
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DisclosuresEditorial BoardsConsilium Infectiorum by InfectoPharm, Infection
DisclosuresEditorial BoardsConsilium Infectiorum by InfectoPharm, Infection