Fluid Resuscitation in African Children with Severe Infection

In African children with fever and impaired perfusion, fluid-bolus resuscitation was associated with increased 48-hour mortality.

In resource-rich medical settings, fluid boluses of ≤60 mL/kg are recommended for children presenting with fever and shock. Nonresponsiveness to such treatment signals the need for intensive care. In resource-limited countries where intensive care units are unavailable, the role of fluid resuscitation is unknown.

In a two-stratum study conducted at six centers in Kenya, Tanzania, and Uganda, investigators assessed fluid-resuscitation strategies in 3170 children aged 60 days to 12 years who had fever, impaired consciousness, respiratory distress, and impaired perfusion. In Stratum A, 3141 children without severe hypotension were randomized to receive a 20- to 40-mL/kg bolus of either saline solution or albumin solution or no bolus. In Stratum…

Reviewing Author

Robert S. Baltimore, MD

Disclosures

Editorial BoardsInfectious Diseases in Children

Leadership Positions in Professional SocietiesMember Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease

Robert S. Baltimore, MD

Disclosures

Editorial BoardsInfectious Diseases in Children

Leadership Positions in Professional SocietiesMember Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease

Fluid Resuscitation in African Children with Severe Infection

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Reviewing Author