Pneumococcal Vaccination Effects on Carriage and Invasive Disease in Children

Pneumococcal serotypes covered by the 7-valent vaccine were replaced by serotypes with lower invasiveness potential, resulting in a net reduction in invasive pneumococcal disease.

More than 90 Streptococcus pneumoniae serotypes have been described. PCV7 — a vaccine that induces antibodies against the seven serotypes responsible for most episodes of invasive pneumococcal disease (IPD) — was introduced into childhood vaccination schedules in the U.S. in 2000 and in the U.K. in 2006. Now, researchers have examined the effect of PCV7 on IPD incidence and serotype distribution in the U.K.

Between April 2008 and November 2009, nasopharyngeal swabs were obtained from children born since September 4, 2004, and their family members, all recruited from general practices in Hertfordshire and Gloucestershire. Pneumococci were grown from 127 of 382 swabs (33.2%); serotypes were determined for 123. These data were compared to findi…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Pneumococcal Vaccination Effects on Carriage and Invasive Disease in Children

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Reviewing Author