Early Pseudomonas Infections in Children with CF: Four Regimens Compared

Although the regimens were equally efficacious in preventing exacerbations, culture-based therapy was most efficient; adding oral ciprofloxacin to inhaled tobramycin provided no benefit.

In children with cystic fibrosis (CF), pulmonary deterioration may be delayed by aggressive treatment with antibiotics (oral, inhaled, or both) early after Pseudomonas aeruginosa (Pa) infection is first detected. In a recent multicenter, controlled trial, investigators assessed the efficacy and safety of four such regimens.

The study involved 304 children with CF, aged 1 to 12 years, who were recruited from 55 U.S. clinical centers; all had Pa newly isolated from the respiratory tract within the preceding 6 months. The children were randomized to receive one of four treatments for 18 months:

Scheduled tobramycin inhalation plus oral ciprofloxacin, every 3 months
Scheduled tobramycin inhalation plus oral placebo, every 3 months
Tobramycin inhala…

Reviewing Author

Robert S. Baltimore, MD

Disclosures

Editorial BoardsInfectious Diseases in Children

Leadership Positions in Professional SocietiesMember Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease

Robert S. Baltimore, MD

Disclosures

Editorial BoardsInfectious Diseases in Children

Leadership Positions in Professional SocietiesMember Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease

Early Pseudomonas Infections in Children with CF: Four Regimens Compared

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Reviewing Author