Lack of Varicella Reexposure Not Associated with Increased Zoster Risk

In France, where varicella vaccination is not routine, zoster occurred in 16% of monks and nuns without exposure to children and 15% of the general population.

Herpes zoster (HZ), which is caused by reactivation of varicella zoster virus (VZV), is hypothesized to occur at an increased rate among individuals without reexposure to VZV after a childhood bout of chickenpox. This hypothesis has important implications regarding universal childhood VZV vaccination: If repeated exposures are protective against subsequent reactivation, then vaccination will result in an increased risk for HZ later in life. To explore this issue, researchers conducted a multicenter, observational study in France, where children do not routinely receive VZV vaccine. The study was funded by a vaccine manufacturer.

The researchers sent questionnaires to members of contemplative monastic orders in 40 monasteries and to the gener…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)