Fecal Carriage Is a Risk Factor for Infections by ESBL-Producing Enterobacteriaceae

In a 10-year study conducted in France, pretransplant carriage was an independent risk factor for ESBLE infection after liver transplantation.

Infections caused by extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBLE) are becoming more common globally. Investigators at a transplant center in France recently conducted an observational study to assess the incidence of and risk factors for such infections after liver transplantation (LT).

During the 10-year study period (January 2001 through April 2010), 710 LT patients were screened preoperatively for fecal ESBLE using rectal swab specimens obtained on the day of surgery. Patients routinely received intraoperative cefoxitin prophylaxis.

Pretransplant fecal ESBLE carriage was found in 29 of the 710 patients (4.1%), with the proportion of carriers increasing from 0% in 2001–2003 to 10.6% in 2009–2010. Overall, 39 patients (…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine