Short-Course Treatment for Acute Pyelonephritis?

In women with acute pyelonephritis, a 7-day course of ciprofloxacin was not inferior to a 14-day course.

Although acute pyelonephritis is common in women, few controlled trials have been done to assess the optimum duration of therapy for this infection. To provide more data, researchers in Sweden conducted a prospective, multicenter, noninferiority trial of ciprofloxacin for 7 days and 14 days.

A total of 248 nonpregnant women aged ≥18 with community-acquired acute pyelonephritis (fever ≥38°C and ≥1 sign or symptom related to the urinary tract) were randomized to short- or longer-course therapy. During the first week, all participants received oral ciprofloxacin (500 mg twice daily); during the second week, women in the short-course group received placebo, and those in the longer-course group continued on ciprofloxacin. Participants were hospit…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine