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How best to use adjunctive corticosteroid therapy for adults with bacterial meningitis has not been straightforward. The strongest support for such therapy came from a large randomized, controlled trial performed in Europe that suggested a benefit in the treatment of pneumococcal meningitis, but not meningococcal meningitis (JW Infect Dis Dec 20 2002); two studies conducted in developing countries yielded disparate results (JW Infect Dis Dec 12 2007). A new report provides further insights into the use of adjunctive dexamethasone in adults with meningococcal meningitis.
The researchers assessed data from two prospective, nationwide cohort studies performed in the Netherlands on community-acquired bacterial meningitis. One was conducted from …