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Recurrent urinary tract infections (UTIs) are common, especially among women. Recent research has suggested that invasion of bladder epithelial cells by uropathogenic Escherichia coli — and persistence of these bacteria in quiescent intracellular reservoirs — may underlie such recurrence. Statins have been found to interfere with the bacterial invasion of cells, providing a rationale for studying the clinical effect of statins on recurrent UTIs.
Toward this end, researchers in the Netherlands linked data from PREVEND IT (a randomized trial to examine whether use of pravastatin, fosinopril, or both might prevent cardiovascular and renal disease in nonhypertensive, nonhypercholesterolemic adults with microalbuminuria) with a large prescription…