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Antibiotic resistance in Neisseria gonorrhoeae is of increasing concern, with azithromycin-resistant strains identified in California in 2011 (JW Infect Dis Jun 8 2011) and treatment failures in Asia and Europe because of rising minimum inhibitory concentrations (MICs) for cephalosporins. In July 2011, the CDC reported a rising prevalence of N. gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone among men attending publicly funded sexually transmitted disease (STD) clinics in the U.S. (JW Infect Dis Jul 20 2011), and now treatment failure caused by such strains has been identified in patients treated at a Toronto STD clinic.
Researchers retrospectively reviewed the clinical outcomes of patients who were treated with …