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Although dietary interventions for secondary prevention of coronary heart disease are popular among patients and doctors, there is no consensual evidence of the beneficial effects of many dietary supplements, including vitamins and fish oil. In the randomized, open-label, Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione study of 11,324 recent-MI patients, investigators compared the effects of n-3 polyunsaturated fatty acids (PUFA; 1 g daily), vitamin E (300 mg daily), both supplements, and no supplements on the combined primary endpoint of death, nonfatal MI, and stroke over 3.5 years. Intention-to-treat analyses were completed by factorial design (two-way) and treatment group (four-way).
Treatmen…