Off-Pump vs. On-Pump CABG: 5-Year Data

Cardiovascular outcomes were similar at 5 years, and the rate of cognitive decline was 50% with each type of surgery.

Cognitive decline has been reported in many patients who undergo coronary artery bypass grafting (CABG). In the Octopus Study, a randomized comparison of off-pump and on-pump CABG in 281 low-risk patients (mean age, 61; 68% men), the two groups did not differ significantly in their rates of mortality, stroke, or cognitive decline at 3 months or at 1 year (Journal Watch Cardiology Apr 26 2002). Now, we have data from the 260 subjects who survived to the 5-year evaluation.

At 5 years, 50% of each group exhibited cognitive decline, defined as a ≥20% decrease in performance on at least 3 of 11 neuropsychological test variables. Only older age and lower level of education were associated with cognitive decline in a multivariable analysis. The 5-y…

Reviewing Author

Harlan M. Krumholz, MD, SM

Off-Pump vs. On-Pump CABG: 5-Year Data

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Reviewing Author