Improving Endothelial Function via . . . the Gums?

Intensive treatment of severe periodontitis improved endothelial function in a randomized, controlled trial that did not track long-term outcomes.

Some research has suggested an association between periodontitis and cardiovascular disease, possibly mediated by systemic inflammation. In a new study of endothelial function and biomarkers of inflammation, researchers randomized patients with severe periodontitis to receive intensive treatment for that condition or standard, community-based periodontal care. Of 1079 patients initially screened, 120 eligible patients (mean age, 48; 50% men) were randomized; 114 completed the study.

Periodontal outcomes were significantly better with intensive treatment than with standard care at both 2 months and 6 months. At 24 hours, the intensively treated group exhibited worse endothelial function (assessed by flow-mediated dilatation) and worse nitrogl…

Reviewing Author

Harlan M. Krumholz, MD, SM