State-of-the-art technology has enabled researchers to identify several chromosomal associations that warrant investigation.
The emergence of high-density genotyping arrays that can assess the entire genome is rapidly changing the investigation of genetic associations with disease. In two case-control studies, the Wellcome Trust Case Control Consortium (WTCCC) and the German MI Family Study, investigators used the GeneChip Human Mapping 500K Array Set, which can simultaneously type about 500,000 genetic variants, to test for genetic associations with coronary artery disease and MI.
In the WTCCC study, cases consisted of 1988 subjects with a strong family history of MI, plus MI or coronary revascularization before age 66. The German MI Family Study enrolled 875 case subjects with an MI before age 60 and at least two first-degree relatives with premature MI. The cas…
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DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association