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The Framingham cardiovascular risk equations were developed during the peak incidence of cardiovascular disease in the U.S. They perform well in similar populations but may overestimate risk in some contemporary European populations. In addition, the Framingham algorithm does not include factors such as social deprivation, body-mass index, family history of CVD, and current treatment with antihypertensive drugs. To develop a new model that includes these factors (the QRISK score), researchers revised and calibrated estimates of CVD risk for a contemporary U.K. population; to validate the new model, they compared it with the Framingham algorithm and the ASSIGN equations used in Scotland. The derivation cohort consisted of 1.28 million patien…