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Apolipoprotein E (apo E) is essential in the metabolism of cholesterol and triglycerides and helps to clear chylomicrons and very-low-density lipoproteins. Several small studies and an earlier review have demonstrated variation in cholesterol levels and coronary disease risk associated with apo E isoforms. These investigators conducted a meta-analysis to assess the relation of apo E genotypes to LDL cholesterol (LDL-C) and coronary disease risk. They identified 82 studies of lipid levels (involving data on some 86,000 healthy participants) and 121 studies of coronary outcomes (involving data on some 38,000 cases and 83,000 controls) from both published and unreported sources.
Pooling the lipid studies, researchers found a roughly linear rela…