Persistent Hyponatremia in Patients with Heart Failure

Persistent hyponatremia independently predicted mortality as well as rehospitalization in patients hospitalized with HF.

Because of its established association with adverse outcomes, hyponatremia is considered an important marker of heart failure severity. These researchers investigated whether persistent hyponatremia during hospitalization predicts outcomes.

Using data from ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness), the investigators studied the associations between outcomes and baseline hyponatremia and changes in serum sodium levels in 433 patients hospitalized with severely symptomatic HF and LV systolic dysfunction (LV ejection fraction, <30%). At baseline, 103 patients had hyponatremia. After 6 months of follow-up, baseline hyponatremia was associated with a higher risk for death (hazard rati…

Reviewing Author

Frederick A. Masoudi, MD, MSPH

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)