Probing the Genetics of Deep Venous Thrombosis

In a study of data from three case-control studies, researchers identified several SNPs that may contribute to DVT risk.

Deep venous thrombosis is a major clinical problem. Findings from observational studies indicate that genetic factors may account for as much as 60% of the risk for DVT – yet the genetic underpinnings of inherited traits associated with DVT are poorly understood.

Investigators used three case-control studies of patients with first-incidence DVT to conduct a wide-ranging search for associated gene variants. Nearly 20,000 single nucleotide polymorphisms (SNPs) were genotyped in pooled DNA samples from 443 cases and 453 controls in the Leiden Thrombophilia Study (LETS). The researchers identified 1206 SNPs associated with DVT and tested them in 1398 cases and 1757 controls comprising a subset of the Multiple Environmental and Genetic Assessment…

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)