Paraoxonase 1, Oxidative Stress, and Atherosclerosis

A polymorphism of PON1 is found to have both biochemical and clinical associations with cardiovascular disease.

Oxidative stress is an important factor in the development of atherosclerosis. Paraoxonase 1 (PON1), an enzyme associated with HDL, has been reported to have important antioxidant, anti-inflammatory, and cardioprotective actions, and the genetic deletion of PON1 is associated with increased atherosclerosis in animal models. Little is understood, however, about the relation between genetic polymorphisms of PON1 and its functional activity in humans. Therefore, investigators assessed the associations among the Q192R polymorphism of PON1, measures of PON1 activity (using paraoxonase and arylesterase assays), and both prevalent cardiovascular disease and adverse cardiovascular events in 1399 patients undergoing diagnostic angiography at the Cle…

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)