Late Percutaneous Coronary Intervention After MI: A Meta-Analysis

PCI between 12 hours and 60 days after acute MI was associated with better long-term survival and cardiac function than medical therapy was.

Reperfusion of the infarct-related artery in stable patients >12 hours after acute MI is controversial because of contradictory results from mostly small observational and randomized studies. To examine this issue further, researchers conducted a meta-analysis of pooled data from 10 randomized controlled trials involving 3560 stable acute MI patients, approximately 60% of whom were enrolled in the Occluded Artery Trial (OAT; Journal Watch Cardiology Nov 14 2006). The average median time from acute MI to percutaneous coronary intervention was 12 days, and the average median follow-up duration was 2.8 years.

The primary endpoint, all-cause mortality, was better with PCI than with medical therapy: 112 deaths (6.3%) versus 149 deaths (8.4%), res…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI