A One-Two Punch for Coronary Risk in Patients with Diabetes

Findings from a case–control and independent-cohort study suggest that genotype and poor glycemic control interact to predict CAD in diabetic patients.

A genetic variant located on chromosome 9p21 is a confirmed risk factor for coronary artery disease, but the magnitude of its effect in patients with diabetes is not well understood. Therefore, investigators performed a case–control study of type 2 diabetic individuals with (n=322) or without (n=412) angiographically diagnosed CAD; patients were recruited between 2001 and 2006 in Boston. In addition, the researchers studied an independent cohort of 475 type 2 diabetic individuals recruited between 1993 and 1996 and followed up through December 2004. All participants were genotyped for a representative single nucleotide polymorphism (SNP) at 9p21 (rs2383206) and assessed for glycemic control by HbA_1c level at baseline and, if possible, by a …

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

A One-Two Punch for Coronary Risk in Patients with Diabetes

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Reviewing Author