Long-Term Follow-Up After Alcohol Septal Ablation

Alcohol septal ablation was effective in treating hypertrophic obstructive cardiomyopathy, with benefits persisting during 10 years of follow-up.

For more than 40 years, hypertrophic obstructive cardiomyopathy (HOCM) has been treated by surgical myomectomy; alcohol septal ablation (ASA) was introduced for this condition in 1995. In this study, investigators report long-term outcomes of 629 patients with HOCM (mean age, 54) who underwent ASA between 1996 and 2006. Patients’ mean LV outflow tract (LVOT) gradient at baseline was 77 mm Hg at rest (80% of patients) or 74 mm Hg after provocation (20%). A mean of 1.3 septal arteries were injected with a mean of 2.6 mL of ethanol per patient. Acute procedural success was achieved in 619 patients (98.4%).

In-hospital complications included death (1.0%), coronary dissection (1.3%), and heart block requiring a new permanent pacemaker (9.7%). Mea…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI