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The physician-editors of Journal Watch Cardiology have the pleasure of providing our perspective on key published studies in our field. At the end of each year, we review the studies we have covered and highlight the ones that have the most important implications for clinical practice. Many of this year’s notable studies raised more questions than they resolved, but findings that force us to question our assumptions can be just as valuable as those that expand the cutting edge of practice. Here are our choices for 2008.
Several studies reminded us that knowing how a drug affects a surrogate marker for disease or disease severity is not the same as knowing how it affects patient outcomes. Sales of ezetimibe grew to $5 billion based only on ev…