Diastolic Dysfunction Predicts Poor Exercise Capacity

Obtaining echocardiographic measures of diastolic function might identify patients at high risk for exercise intolerance.

Few data are available on the association of LV function with exercise capacity. Some study findings have suggested that diastolic dysfunction is related to poor exercise capacity, particularly in older individuals. In this cross-sectional study from the Mayo Clinic, investigators enrolled 2867 patients undergoing exercise testing and assessed clinical and echocardiographic correlates of exercise capacity as measured in METs.

Routine echocardiographic measures of systolic and diastolic function obtained before and after exercise revealed that diastolic dysfunction correlated inversely with exercise capacity. After multivariate adjustment, individuals with mild or moderate-to-severe resting diastolic dysfunction had significantly less exercis…

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

Diastolic Dysfunction Predicts Poor Exercise Capacity

Topics

Reviewing Author