Does Glucose Normalization Improve Outcomes After Acute MI?

Observational data suggest that it does, regardless of whether it is achieved with insulin treatment.

High blood glucose levels on hospital admission are associated with decreased survival after acute MI. To find out whether normalization of blood glucose after admission affects mortality, investigators used two metrics — admission and mean postadmission glucose levels — to study 7820 hyperglycemic patients hospitalized for acute MI between January 1, 2000, and December 31, 2005.

Heart failure and diabetes were more prevalent in patients with higher postadmission glucose levels than in those with lower postadmission glucose levels. Lower postadmission glucose levels were associated with lower mortality; this association persisted after multivariate adjustment (see table).

When admission and postadmission glucose levels were included in multiv…

Reviewing Author

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

Does Glucose Normalization Improve Outcomes After Acute MI?

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Reviewing Author