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Idiopathic ventricular fibrillation (VF) is defined as cardiac arrest in which the results of a reasonable cardiac work-up — including electrocardiogram, catheterization or stress test, and echocardiography — are normal. Idiopathic VF accounts for a sizable fraction of all cardiac arrests, especially in younger patients.
In this study, patients with initial diagnoses of idiopathic VF at nine centers in Canada underwent a systematic, exceptionally thorough work-up. Evaluation included the standard tests described above plus cardiac magnetic resonance imaging, exercise testing and adrenaline challenge to examine for long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPMVT), procainamide administration to examine…