High-Dose Statins Before Percutaneous Coronary Intervention

In statin-naive patients, a single loading dose of atorvastatin within 24 hours before PCI significantly reduced the rate of periprocedural MI.

Several studies have demonstrated that patients who receive statins before percutaneous coronary intervention are less likely to have a periprocedural MI than are those who do not receive preprocedural statins (JW Cardiol Aug 19 2009). In this two-center, placebo-controlled, randomized trial, investigators in Italy examined whether this beneficial effect could be achieved with a single 80-mg dose of atorvastatin administered on the day of the procedure.

A total of 668 statin-naive patients with de novo lesions underwent randomization and treatment with stenting. The primary endpoint of creatine kinase-MB elevation >3 times the upper limit of normal (ULN) occurred in 9.5% of statin-treated patients and in 15.8% of controls (odds ratio, 0.56; …

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)