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The efficacy of dual antiplatelet therapy with aspirin and clopidogrel in patients undergoing percutaneous coronary intervention is well established. However, patient response varies widely, and insufficient platelet inhibition is associated with increased risk for adverse coronary events. Several platelet function assays are available, but no consensus exists on whether or how to use them to quantify on-treatment platelet reactivity in stent recipients.
In a Dutch single-center, prospective cohort study, investigators compared the performance of platelet function assays in 1069 patients (mean age, 64; 75% men) who began dual antiplatelet treatment before elective stent implantation. If possible, on-treatment platelet reactivity was measured…