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Despite the availability of several antihypertensive drug classes and numerous individual agents, hypertension remains poorly controlled in many patients. Improving control rates will require tailoring of therapy to individual patient factors. In a recent issue of the American Journal of Hypertension, three studies address the heterogeneity of response to various antihypertensive drugs, and two editorialists use the findings to propose novel treatment paradigms.
Two studies highlight inter-individual responses to treatment. Turner and colleagues found that measures of plasma renin activity (PRA) predicted patient responses to atenolol or hydrochlorothiazide, both as monotherapy and as add-on therapy, independently of patient age, race, and p…