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Heart failure (HF), although considered primarily a condition of cardiac function, is also characterized by numerous noncardiac disturbances, including impaired skeletal and muscular function and metabolic disorders such as low androgen levels and impaired insulin sensitivity. Low testosterone levels in HF patients are associated with functional impairment, and in small studies including only men, testosterone replacement produced improvements in functional capacity and insulin sensitivity. However, until now, the effects of testosterone replacement in women with HF had not been studied.
Investigators randomized 36 postmenopausal women (mean age, 68) with clinically stable left ventricular (LV) systolic function but New York Heart Associatio…