Worsening Diastolic Function Predicts Heart Failure

Progression of diastolic dysfunction is an independent risk factor that warrants vigilance but not — at this point — screening or intervention.

Left ventricular (LV) diastolic dysfunction is an important precursor of heart failure (HF). However, change in diastolic function over time has not been correlated with the development of overt HF. This study involved 1402 participants in the Olmsted County Heart Function Study (mean age, 61; 90% white; 49% men) who underwent two clinical and echocardiographic evaluations 4 years apart. At the first examination, 2.3% of the population had abnormal systolic function. Diastolic function, assessed at both examinations in 75.5% of participants, was characterized as normal, mild (abnormal relaxation without increased LV end-diastolic pressure [LVEDP]), moderate (abnormal relaxation with increased LVEDP), or severe (reduced LV compliance with re…

Reviewing Author

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Worsening Diastolic Function Predicts Heart Failure

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Reviewing Author