Even with Anticoagulation Therapy, Higher CHADS2 Scores Predict Worse Outcomes

In a RE-LY substudy, the correlation was present and similar in all treatment arms.

The CHADS₂ (Congestive heart failure, Hypertension, Age ≥75, Diabetes, Stroke history [2 points]) risk score for stroke was validated in patients with atrial fibrillation (AF) who were not treated with an anticoagulant. To evaluate CHADS₂ as a predictor of stroke in AF patients taking anticoagulants, investigators conducted subgroup analyses of data from the RE-LY trial of dabigatran versus warfarin in patients with AF (JW Cardiol Sep 1 2009).

Dividing the RE-LY cohort (>18,000 patients) into rough tertiles according to CHADS₂ score resulted in three subgroups with scores of 0–1, 2, and 3–6, respectively. Baseline characteristics differed significantly among the subgroups; of patients with CHADS₂ scores of 3–6, >90% had hypertension, and mos…

Reviewing Author

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

Even with Anticoagulation Therapy, Higher CHADS₂ Scores Predict Worse Outcomes

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Reviewing Author