Risk factors are less prevalent than in the past, but they are just as predictive of outcome.
In the Cardiovascular Lifetime Risk Pooling Project, investigators conducted an individual-level meta-analysis of data from 18 cohort studies to calculate lifetime risk for cardiovascular events based on demographic characteristics and risk factors. The pooled analysis included 67,890 participants in 17 studies; data on 189,494 participants in MRFIT were analyzed separately because of cohort size.
At an index age of 55, the lifetime risk for death from cardiovascular disease in the pooled cohort was 36% in white men, 33% in black men, 27% in white women, and 27% in black women. The lifetime risk for cardiovascular death was about 6 times higher in individuals with ≥2 cardiovascular risk factors than in those with optimal risk-factor profiles…
Reviewing Author
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association